Recombinant Fetuin A Proteins

Recombinant Fetuin A proteins are powerful tools for research into mineralization, immune modulation, and metabolic regulation. Produced through advanced recombinant protein expression systems, these proteins offer high purity, consistent activity, and precise control for a wide range of scientific studies. Whether you’re exploring calcification disorders, chronic inflammation, or metabolic syndromes, Beta LifeScience offers reliable recombinant solutions to support your research goals.

Fetuin A—also known as alpha-2-HS-glycoprotein (AHSG)—is a glycoprotein synthesized mainly in the liver and secreted into the bloodstream. It plays an essential regulatory role in mineral metabolism, where it binds calcium and phosphate ions to prevent unwanted precipitation and soft tissue calcification. Because of this unique ability, Fetuin A proteins are crucial in maintaining the delicate balance between healthy bone formation and pathological mineralization.

Biological Roles of Fetuin A

Fetuin A is not just another plasma protein—it’s a multifunctional molecule influencing several physiological and pathological processes. As a calcium-binding glycoprotein, Fetuin A inhibits the formation of basic calcium phosphate crystals, which could otherwise lead to vascular and soft tissue calcification. This protective role has made it a major target in studies of cardiovascular disease and kidney dysfunction, where abnormal calcification is common.

Beyond mineral regulation, Fetuin A also modulates the immune response. It can act as an endogenous anti-inflammatory agent, controlling the activity of pro-inflammatory cytokines and immune cells. This function is particularly important during systemic inflammation or metabolic stress.

In the context of metabolism, low Fetuin A levels have been linked to insulin resistance and type 2 diabetes. Researchers are investigating how alterations in Fetuin A expression influence glucose tolerance and fat metabolism. As such, recombinant Fetuin A proteins provide a critical tool for modeling these pathways and screening potential therapeutic targets.

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Why Use Recombinant Fetuin A Proteins?

Recombinant production of Fetuin A allows scientists to work with a consistent and bioactive version of the protein that mimics its natural structure and function. These proteins are engineered using mammalian cell expression systems, ensuring proper folding, glycosylation, and biological activity.

Some of the core benefits of using recombinant Fetuin A proteins in your experiments include:

• High Purity: Each protein batch is rigorously tested to ensure ≥95% purity using SDS-PAGE and HPLC analysis.
• Reliable Activity: Functional assays confirm protein activity, including cell-based testing and IC50 or ED50 values for active proteins.
• Species Variants: Beta LifeScience offers human, mouse, and Macaca mulatta versions to support cross-species research.
• Flexible Applications: Useful in studies related to vascular calcification, immune modulation, diabetes, obesity, and bone remodeling.

Our Recombinant Proteins are produced under stringent quality control standards and are available in multiple configurations, including His-tagged and untagged forms.

Applications of Recombinant Fetuin A in Research

The scientific value of Fetuin A spans multiple disciplines, making it a versatile tool in many labs. Some of the common applications include:

• Cardiovascular Research: Investigate the protective role of Fetuin A against arterial calcification and its association with atherosclerosis.
• Bone and Mineral Studies: Examine how Fetuin A regulates calcium-phosphate homeostasis and influences osteoblast or osteoclast function.
• Inflammation & Immune Response: Explore Fetuin A’s effect on macrophage activation, cytokine expression, and systemic inflammatory markers.
• Metabolic Disease Research: Study how Fetuin A levels impact insulin sensitivity, glucose uptake, and lipid metabolism in models of obesity or type 2 diabetes.
• Nephrology: Assess the role of Fetuin A in chronic kidney disease, where impaired mineral balance can lead to widespread soft tissue calcification.

These use cases are just the beginning—ongoing research continues to reveal new roles and mechanisms involving Fetuin A in health and disease.

Explore Related Recombinant Protein Collections

If your work involves other proteins linked to inflammation or metabolism, Beta LifeScience offers an extensive lineup of ready-to-ship options. Browse our curated In-Stock Recombinant Proteins for fast, reliable access to functional proteins.

For studies involving immune system regulators and inflammation, check out our Interleukins Collection, which features active cytokines essential for cell signaling.

Looking into cell regeneration and repair mechanisms? Our Growth Factors category includes proteins that drive proliferation, differentiation, and healing in various tissue types.

And if your work intersects with signal tracking or detection, consider our Phycobiliproteins, ideal for use as fluorescent markers.

Why Choose Beta LifeScience?

At Beta LifeScience, quality and consistency are at the heart of everything we offer. Each Recombinant Fetuin A product undergoes strict validation to ensure optimal purity and activity. With detailed protein information available for every product—such as amino acid sequence, host cell type, tag location, and bioassay data—you get full transparency and control for your experiments.

Our recombinant proteins are ideal for academic, industrial, and clinical research settings, backed by responsive customer support and reliable worldwide shipping. Whether you’re studying Fetuin A’s role in calcification or exploring its therapeutic potential, you can trust our collection to deliver results you can build on.

Order Recombinant Fetuin A Proteins with Confidence

When precision matters, choose a partner that delivers trusted biological reagents. Recombinant Fetuin A Proteins from Beta LifeScience provide a consistent, scalable solution for labs studying calcium metabolism, inflammatory disorders, and metabolic disease.

Ready to take the next step in your research? Browse our full catalog of recombinant proteins or get in touch with our scientific support team for custom solutions or bulk inquiries.

FAQs

What are Recombinant Fetuin A Proteins used for?

Recombinant Fetuin A Proteins are commonly used in studies focused on bone mineralization, vascular calcification, inflammation, and metabolic disorders. Researchers use them to understand how Fetuin A regulates calcium balance, immune response, and insulin sensitivity.

How is recombinant Fetuin A different from natural Fetuin A?

Recombinant Fetuin A is produced in controlled lab settings using genetic engineering. This method ensures high purity, consistent quality, and better reproducibility compared to proteins isolated from natural sources.

Which species are available for Fetuin A Proteins?

Beta LifeScience offers recombinant Fetuin A proteins from multiple species, including human, mouse, and Macaca mulatta. These options support a wide range of comparative and cross-species research.

Are the Fetuin A Proteins active?

Yes, select recombinant Fetuin A proteins in our catalog are bioactive and tested in functional assays. Check each product description for activity data, such as ED50 or IC50 values, where available.

Can I use Recombinant Fetuin A Proteins for in vivo research?

While our proteins are designed for high-quality research applications, we recommend verifying the endotoxin level and formulation details to determine suitability for in vivo use. Reach out to our support team for specific technical documentation.