Recombinant Interleukin-6 (IL-6) Proteins
12 products
Interleukin-6 (IL-6) plays a crucial role in regulating immune function and inflammation. Beta LifeScience offers high-purity Recombinant Interleukin-6 proteins developed to support advanced research into immune signaling, inflammatory pathways, and disease mechanisms. Whether you're investigating cytokine behavior, autoimmune triggers, or therapeutic targets, our IL-6 proteins are built to deliver consistent and active performance.
These recombinant proteins are designed for compatibility with a variety of cell-based assays and experimental models. With products available across multiple species—including human, mouse, rat, and rhesus, we ensure flexibility for cross-species studies and comparative immunology research. Each IL-6 protein is produced under strict quality controls to maintain bioactivity, purity, and reproducibility across batches.
What Is Interleukin 6?
Interleukin 6 (IL-6) is a pro-inflammatory cytokine secreted by immune cells such as T cells, B cells, monocytes, and macrophages. It’s a key player in the early stages of immune response and serves as a communication bridge between innate and adaptive immunity. When the body experiences injury or infection, IL-6 is rapidly produced to signal inflammation, mobilize immune cells, and kickstart the healing process.
Beyond inflammation, IL-6 functions extend into hematopoiesis (blood cell formation), metabolic regulation, and even neural development. This wide biological scope makes IL-6 one of the most studied cytokines in immunology and molecular biology.
IL6 Functions and Biological Importance
- Regulates Immune Response: IL-6 activates T cell differentiation and boosts B cell antibody production. It’s essential for host defense during infections.
- Acute Phase Response Mediator: IL-6 promotes the liver’s release of acute phase proteins like C-reactive protein (CRP), a major marker of inflammation.
- Supports Tissue Repair: By regulating cell proliferation and apoptosis, IL-6 aids wound healing and tissue regeneration.
- Drives Inflammatory Diseases: Persistent elevation of IL-6 levels is linked to chronic inflammation, arthritis, autoimmune disorders, and cancer progression.
- Influences Metabolism and Aging: Emerging studies suggest IL-6 impacts lipid metabolism and may contribute to age-related disorders.
Given this complexity, recombinant IL-6 proteins are a vital tool in understanding disease progression and developing targeted therapies.
Why Study Recombinant Interleukin-6?
Recombinant Interleukin-6 allows researchers to study cytokine function in a controlled environment. Unlike native proteins, recombinant IL-6 ensures consistency in structure and activity, making experimental outcomes more reliable. These proteins can be used to activate specific signaling pathways, simulate disease conditions, or evaluate immune responses in various systems.
At Beta LifeScience, our IL-6 proteins are expressed in different hosts (E. coli, yeast, mammalian cells) and tagged for easy purification and downstream processing. They are verified for high purity using SDS-PAGE and validated through biological assays such as ELISA, HPLC, and cell-based testing.
Applications of Recombinant IL-6
- Immunological Research: Understand how IL-6 shapes adaptive and innate immune responses. Track T cell behavior, study cytokine receptor binding, or model inflammatory reactions.
- Autoimmune Disease Models: Use recombinant IL-6 to explore disease mechanisms in models of rheumatoid arthritis, multiple sclerosis, or lupus. Investigate how IL-6 inhibitors alter disease progression.
- Cancer and Oncology: IL-6 is implicated in tumor growth and metastasis. Recombinant IL-6 proteins are often used to assess cancer cell proliferation, angiogenesis, and resistance pathways.
- Pharmacological Testing: Validate drug candidates targeting the IL-6 signaling pathway by introducing controlled levels of recombinant IL-6 into preclinical studies.
- Regenerative Medicine: Since IL-6 contributes to tissue regeneration, it’s used in studies focused on wound healing, organ repair, and cellular reprogramming.
Clinical Relevance of IL-6
Overexpression of IL-6 interleukin is a hallmark of many diseases. Chronic inflammation, autoimmune disorders, cardiovascular diseases, and even depression have shown strong links to elevated IL-6 activity. That’s why targeting this cytokine has become a therapeutic priority. FDA-approved drugs like tocilizumab, which block IL-6 receptors, highlight the importance of IL-6 research in clinical settings.
What is Interleukin 6’s therapeutic significance? Understanding its signaling network can help reduce cytokine storms in infections like COVID-19, manage autoimmune flare-ups, and potentially slow down cancer growth.
Resources
IL-6 Blog Articles
Unveiling the Significance of Interleukin-6 (IL-6) in Health and Disease
Recombinant IL-6 Proteins Available
We offer a wide variety of Recombinant Interleukin-6 proteins tailored for research needs:
Featured Products
| Cat. No. | Species | Product Description | Host | Structure | Purity | Activity | Features |
|---|---|---|---|---|---|---|---|
| BL-1698NP | Human | Human IL-6 Protein, Active | E. coli | P05231 (30-212aa) | ≥ 95% | ED50: 20-100 pg/mL | SDS-PAGE, Cell Based Assay |
| BLC-05412P | Human | Human IL-6 Protein, Active, GMP | E.Coli | P05231 (30-212aa) | ≥ 98 % | ED50: < 0.1 ng/mL | SDS-PAGE, HPLC, Cell Based |
| BLC-05399P | Human | Human IL-6 Protein, Active | E.Coli | P05231 (30-212aa) | ≥96% | ED50: 0.1 ng/mL | SDS-PAGE, HPLC, Cell Based Assay |
| BLC-05345P | Human | Human IL-6 Protein, Active | E.coli | P05231 (30-212aa) | ≥ 95% | ED50: < 1 ng/mL | SDS-PAGE, Cell Based Assay |
| BLC-04967P | Human | Human IL-6 Protein (His) | E.coli | P05231 (30-212aa) | ≥ 85% | Not Test | SDS-PAGE |
| Human | Human IL-6 Protein | Mammalian cell | P05231 (30-212aa) | ≥ 90% | ED50: 0.2-1 ng/mL | SDS-PAGE, Cell Based Assay | |
| BLPSN-2919 | Human | Human IL-6 Protein | E. coli | P05231 (30-212aa) | ≥ 95 % | The ED50: 0.1-0.8 ng/mL | SDS-PAGE, Cell Based Assay, BLI |
| BLC-05374P | Rhesus macaque | Rhesus Macaque IL-6 Protein | E.Coli | P51494 (28-212aa) | ≥97% | ED50: < 0.1 ng/mL | SDS-PAGE, HPLC, Cell Based Assay |
| BLPSN-2922 | Rhesus | Rhesus IL-6 Protein | E. coli | NP_001036198.2 (29-212aa) | ≥ 85 % | ED50: 5-30 ng/mL | SDS-PAGE, Cell Based Assay |
| BLC-05364P | Mouse | Mouse IL-6 Protein, Active | E.Coli | P08505 (25-211aa) | ≥97% | ED50: < 0.02 ng/mL | SDS-PAGE, Cell Based Assay |
| BLPSN-2920 | Mouse | Mouse IL-6 Protein | E. coli | P08505 (25-211aa) | ≥ 90 % | The ED50: 0.1-0.8 ng/mL. | SDS-PAGE, Cell Based Assay |
| BL-1879NP | Mouse | Mouse IL-6 Protein | E. coli | P08505 (25-211aa) | ≥ 95% | Not Test | SDS-PAGE, HPLC |
| BLPSN-2921 | Rat | Rat IL-6 Protein | E. coli | NP_036721.1 (25-211aa) | ≥ 85 % | ED50: 1-6 ng/mL | SDS-PAGE, Cell Based Assay |
| BLC-09728P | Sheep | Sheep IL-6 Protein (His) | Yeast | P29455 (30-208aa) | ≥ 90% | Not Test | SDS-PAGE |
| BLC-03349P | Sheep | Sheep IL-6 Protein (GST) | E.coli | P29455 (30-208aa) | ≥ 90% | Not Test | SDS-PAGE |
| BLC-04519P | Rabbit | Rabbit IL-6 Protein (His) | Yeast | Q9MZR1 (27-241aa) | ≥ 90% | Not Test | SDS-PAGE |
| BLC-00146P | Llama | Lama Glama IL-6 Protein (His) | E.coli | Q865X6 (26-211aa) | ≥ 90% | Not Test | SDS-PAGE |
| BLPSN-2923 | Pig | Pig IL-6 Protein | E. coli | NP_999564.1 (29-212aa) | ≥ 95 % | ED50: 1-5 ng/mL | SDS-PAGE, Cell Based Assay, ELISA |
All proteins are rigorously tested and quality-assured to ensure they meet research-grade specifications.
Why Choose Beta LifeScience?
- High Purity, Active Proteins: Our IL-6 products are functionally validated and consistently deliver expected biological activity in both in vitro and in vivo applications.
- Batch-to-Batch Consistency: You can count on reliable performance across experiments with minimal variability.
- Wide Range of Species & Tags: Whatever your experimental setup requires, we have flexible formats to match.
- Comprehensive Validation: All IL-6 proteins are validated using SDS-PAGE, ELISA, HPLC, or BLI methods, so you know exactly what you’re working with.
- Fast Global Shipping: We offer worldwide shipping with careful packaging to preserve protein activity.
Support Your Research with Beta LifeScience IL-6 Proteins
At Beta LifeScience, we’re committed to advancing life science innovation with tools that meet the evolving needs of researchers. Our recombinant IL-6 proteins are designed to accelerate your work in immunology, disease modeling, and drug discovery. Whether you're mapping out IL-6 functions in infection or assessing its role in cancer development, you can depend on our expertise, quality, and service.
Explore our full range of Recombinant Interleukin-6 proteins today and elevate your research with precision tools tailored to the front lines of science.
