Recombinant Neuregulin-1 Beta 1 Proteins

Background

Heregulin β-1 (also known as NRG1) is a member of the nerve growth factor family and is involved in a variety of cell signaling and neural development processes. The name of this protein indicates its close association with the nerve growth factor (Neuregulin) family. Heregulin β-1 has multiple isoforms, each expressed differently in tissues and cell types, demonstrating its versatility in physiological and pathological processes.

The main function of Heregulin β-1 is to activate complex signaling pathways by binding to receptors in the nerve growth factor receptor (Neuregulin Receptor) family, such as HER3 and HER4. This is critical for neuronal development, neuronal interactions, as well as the development of cardiomyocytes and the formation of the cardiovascular system.

In the nervous system, Heregulin β-1 is involved in the processes of synapse formation and neuronal migration. In the cardiovascular system, it plays a regulatory role in cardiomyocyte proliferation and heart development. In addition, Heregulin β-1 is also related to the occurrence and development of some tumors, and its abnormal expression is related to the proliferation and invasion of cancer cells, so it has become one of the focuses of cancer research.

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