Recombinant Vitronectin (VTN) Proteins

Vitronectin is a key player in cell biology. As a multifunctional glycoprotein found in plasma and the extracellular matrix, it influences everything from cell adhesion to immune regulation. Its ability to bind integrins and support cell-matrix interactions makes it especially valuable in tissue repair, inflammation studies, and cancer research.

At Beta LifeScience, we offer a curated collection of recombinant Vitronectin proteins — designed for maximum performance in adhesion assays, stem cell culture, and extracellular matrix research. Whether you're studying cell signaling, wound healing, or developing regenerative therapies, our VTN proteins deliver the purity, consistency, and biological relevance your work demands.

Understanding Vitronectin's Role in Research

Vitronectin (VTN) is a versatile glycoprotein that circulates in the bloodstream and binds to various integrins and extracellular molecules. Structurally, it contains domains that interact with collagen, heparin, plasminogen, and PAI-1, allowing it to regulate diverse biological processes.

Its primary function is to promote cell adhesion. Vitronectin achieves this by binding to integrin receptors, such as αvβ3, facilitating cell attachment to the extracellular matrix. This mechanism is essential for maintaining tissue integrity and plays a foundational role in wound healing and embryonic development.

Additionally, Vitronectin influences blood coagulation, acting as a cofactor in platelet aggregation and stabilizing PAI-1. Its involvement in thrombosis and vascular homeostasis has made it a target of interest in cardiovascular research.

In the context of immunity, Vitronectin regulates the activity of monocytes and macrophages, participating in inflammatory signaling. This makes it highly relevant for studies on chronic inflammation and tumor immunology — especially when combined with related molecules from our Interleukins Collection.

Applications of Recombinant Vitronectin

Thanks to its adhesive properties and regulatory effects, recombinant Vitronectin proteins have a wide range of research and therapeutic applications:

Cell Culture & Plate Coating

One of the most common uses of Vitronectin is for coating cell culture plates, especially for pluripotent stem cells (PSCs) and induced pluripotent stem cells (iPSCs). Unlike feeder cell layers or serum, Vitronectin offers a defined, xeno-free environment that supports consistent cell growth and morphology.

Stem Cell & Regenerative Medicine

Recombinant human Vitronectin is widely used in regenerative therapy models. It supports cell survival, proliferation, and differentiation, making it suitable for tissue engineering and scaffold-based systems.

Coagulation & Thrombosis Studies

Its interaction with thrombin and fibrin makes VTN a valuable tool in studying blood coagulation cascades, platelet function, and vascular disorders. In experiments involving wound healing, Vitronectin can be paired with BMP proteins, which guide tissue regeneration and repair.

Tumor Microenvironment Research

Vitronectin’s influence on cell migration and immune evasion makes it an ideal molecule for studying cancer invasion, metastasis, and immune cell interactions within tumors.

Immunological & Inflammatory Research

Changes in VTN levels have been associated with inflammatory diseases. When used alongside cytokines like interleukins, Vitronectin supports deeper analysis of cell signaling and immune activation.

Resources

Product Options for Every Application

We offer a range of high-purity, active, and functionally validated Vitronectin proteins derived from human and mouse sources. Here’s a brief overview of the available catalog:

Featured Products

Each product comes with detailed data sheets, structural info, SDS-PAGE validation, and activity test results where available.

Why Choose Beta LifeScience?

Researchers across biotech, academia, and pharma choose Beta LifeScience because we combine scientific reliability with responsive service. Our recombinant protein collections, including Vitronectin, offer:

Verified Purity and Quality

We conduct rigorous testing to ensure our proteins meet quality standards for bioactivity, structural integrity, and reproducibility.

Species Flexibility

Choose between human and mouse Vitronectin proteins based on your model system. Both options are ideal for cross-species studies or comparative analysis.

Fast Delivery, Global Reach

Our In-Stock Recombinant Proteins are ready to ship within 48 hours. Whether you're running a deadline-driven project or planning for scale-up, we’ve got you covered.

Trusted Support

Need help picking the right construct or deciding between active and non-active formats? Our scientific team is just an email away.

Connecting Vitronectin with Other Research Tools

Vitronectin rarely works alone in a biological system. To support complex study designs, consider pairing VTN proteins with other signaling and matrix-interacting proteins.

For instance, proteins from our BMP Collection are commonly used with Vitronectin in tissue repair and stem cell studies. In immune-based assays, researchers often combine VTN with Interleukins, such as IL-6 or IL-8, to explore inflammatory responses and chemotaxis.

If you're working on imaging or detection, check out our Phycobiliproteins — highly fluorescent proteins that support multi-labeling and live-cell tracking.

Product Use Tips

Here are a few lab-proven tips to get the most out of your recombinant Vitronectin:

• Plate Coating: Dilute the protein in PBS or HEPES buffer at 5–10 μg/mL and incubate on culture plates at 37°C for 1 hour. Rinse gently before seeding cells.
• Storage: Most of our VTN proteins are lyophilized or provided in buffer. Store at -20°C or -80°C depending on the formulation. Avoid repeated freeze-thaw cycles.
• Reconstitution: Use sterile water or PBS to reconstitute lyophilized proteins. Gently mix to avoid denaturation.

Always refer to the product datasheet for detailed reconstitution, storage, and use guidelines.

Ready to Advance Your Research?

Vitronectin is more than a structural protein — it's a gateway to better adhesion, cleaner stem cell cultures, and clearer results in regenerative studies. With high-purity, lab-validated VTN proteins from Beta LifeScience, your work is backed by tools that scientists trust.

Order now and experience the difference — and don’t forget to explore our Growth Factors and Interleukins Collection to expand your experimental toolkit.