Recombinant Thrombopoietin (TPO) Proteins

Recombinant Thrombopoietin (TPO) Proteins

Thrombopoietin (TPO) is an essential growth factor that regulates the formation and maintenance of blood platelets. At Beta LifeScience, we offer a curated range of recombinant TPO proteins produced through high-quality expression systems to ensure excellent purity, activity, and batch-to-batch consistency. These proteins are designed to support advanced research in hematopoiesis, stem cell biology, platelet development, and therapeutic drug screening.

Our in-stock collection includes active human, mouse, and cynomolgus TPO proteins, each validated for quality through SDS-PAGE and cell-based activity assays. Whether you’re studying megakaryocyte differentiation or testing TPO receptor agonists, our recombinant proteins are trusted by researchers to deliver reliable results in critical experiments.

What Is Thrombopoietin (TPO)?

Thrombopoietin, often abbreviated as TPO, is a glycoprotein hormone produced primarily in the liver and kidneys. It plays a central role in the regulation of platelet production, also known as thrombopoiesis. TPO acts by binding to the c-Mpl receptor, a thrombopoietin-specific receptor present on the surface of hematopoietic stem cells (HSCs) and megakaryocyte progenitor cells.

This binding activates multiple downstream signaling pathways that drive the proliferation, maturation, and differentiation of megakaryocytes, which eventually give rise to circulating platelets. Under normal physiological conditions, TPO levels are tightly regulated in response to platelet count. When platelet numbers drop, free TPO levels increase, stimulating the bone marrow to ramp up production.

Aside from its platelet-specific roles, TPO also supports self-renewal of HSCs, contributing to broader hematopoietic homeostasis. Its multifunctional profile makes TPO a powerful tool in both basic biological studies and translational research.

TPO in Hematopoiesis and Disease Research

TPO's significance extends beyond routine platelet production. Dysfunction in TPO signaling or receptor binding can lead to serious hematologic disorders, including:

• Idiopathic Thrombocytopenic Purpura (ITP)
• Aplastic Anemia
• Myelodysplastic Syndromes
• Chemotherapy-induced Thrombocytopenia
  

Recombinant TPO proteins are widely used to model these conditions in vitro and to explore treatment strategies involving TPO receptor agonists. Therapeutic agents like Eltrombopag and Romiplostim mimic TPO’s function and are clinically approved to treat thrombocytopenia. In parallel, recombinant TPO is essential in drug development pipelines for testing efficacy, toxicity, and mechanism of action of emerging compounds.

Recombinant Thrombopoietin (TPO) Proteins

Thrombopoietin (TPO) is an essential growth factor that regulates the formation and maintenance of blood platelets. At Beta LifeScience, we offer a curated range of recombinant TPO proteins produced through high-quality expression systems to ensure excellent purity, activity, and batch-to-batch consistency. These proteins are designed to support advanced research in hematopoiesis, stem cell biology, platelet development, and therapeutic drug screening.

Our in-stock collection includes active human, mouse, and cynomolgus TPO proteins, each validated for quality through SDS-PAGE and cell-based activity assays. Whether you’re studying megakaryocyte differentiation or testing TPO receptor agonists, our recombinant proteins are trusted by researchers to deliver reliable results in critical experiments.

What Is Thrombopoietin (TPO)?

Thrombopoietin, often abbreviated as TPO, is a glycoprotein hormone produced primarily in the liver and kidneys. It plays a central role in the regulation of platelet production, also known as thrombopoiesis. TPO acts by binding to the c-Mpl receptor, a thrombopoietin-specific receptor present on the surface of hematopoietic stem cells (HSCs) and megakaryocyte progenitor cells.

This binding activates multiple downstream signaling pathways that drive the proliferation, maturation, and differentiation of megakaryocytes, which eventually give rise to circulating platelets. Under normal physiological conditions, TPO levels are tightly regulated in response to platelet count. When platelet numbers drop, free TPO levels increase, stimulating the bone marrow to ramp up production.

Aside from its platelet-specific roles, TPO also supports self-renewal of HSCs, contributing to broader hematopoietic homeostasis. Its multifunctional profile makes TPO a powerful tool in both basic biological studies and translational research.

TPO in Hematopoiesis and Disease Research

TPO's significance extends beyond routine platelet production. Dysfunction in TPO signaling or receptor binding can lead to serious hematologic disorders, including:

• Idiopathic Thrombocytopenic Purpura (ITP)
• Aplastic Anemia
• Myelodysplastic Syndromes
• Chemotherapy-induced Thrombocytopenia
  

Recombinant TPO proteins are widely used to model these conditions in vitro and to explore treatment strategies involving TPO receptor agonists. Therapeutic agents like Eltrombopag and Romiplostim mimic TPO’s function and are clinically approved to treat thrombocytopenia. In parallel, recombinant TPO is essential in drug development pipelines for testing efficacy, toxicity, and mechanism of action of emerging compounds.

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Explore Our In-Stock Recombinant TPO Proteins

Our recombinant TPO proteins are derived from mammalian expression systems to ensure correct folding and glycosylation, which are essential for functional biological activity. Here's a look at some of our featured products:

Featured Products

Each product is tested using SDS-PAGE and cell-based assays, and many include ED50 activity measurements to confirm their performance.

Features of Our Recombinant TPO Proteins

At Beta LifeScience, we emphasize scientific precision and consistency. All recombinant TPO proteins are expressed in mammalian cells to preserve proper folding and post-translational modifications, which are critical for biological activity. Here are some features you can expect across our TPO lineup:

• High purity (up to >95%) validated by SDS-PAGE
• Functional bioactivity tested using cell-based assays (ED50 values provided)
• Mammalian expression systems for native-like performance
• Multiple species available: human, mouse, cynomolgus
• Flexible tag options: His-tag, Fc-tag, 6-His tag (N- or C-terminal)

Each product page includes detailed specs for easy comparison and ordering.

Why Choose Beta LifeScience for TPO Proteins?

• High Purity & Activity: All our TPO proteins undergo strict quality checks to ensure purity levels above 85–95%, depending on the product. Activity is confirmed in relevant bioassays.
• Reliable Expression Systems: We use mammalian cells to ensure proteins are folded and modified correctly, preserving their biofunctionality.
• Batch-to-Batch Consistency: Whether you're running a single test or an extended study, you'll get consistent performance from every lot.
• Fast U.S. Shipping: Most in-stock proteins are eligible for 2-day delivery within the U.S. so you can stay on schedule.
• Expert Support: Need help choosing the right TPO variant? Our team is here to answer your questions and guide your purchase.

Applications of Recombinant TPO Proteins

Recombinant TPO is widely used in both basic and translational research:

• Stem Cell Expansion: TPO supports the growth and maintenance of hematopoietic stem cells, especially when combined with cytokines like SCF and IL-3.
• Megakaryocyte Differentiation Studies: Understand how megakaryocytes develop and how TPO impacts platelet generation.
• Thrombocytopenia Modeling: Mimic low platelet conditions for drug testing or disease modeling.
• Preclinical Drug Development: Validate the effects of TPO receptor modulators or test the therapeutic potential of new biologics.

For related research, you may also want to explore our Growth Factors collection for proteins that complement TPO signaling, or browse our full range of In-Stock Recombinant Proteins for additional ready-to-ship options.

Trusted by Researchers Worldwide

At Beta LifeScience, we understand how critical protein quality and speed are to your research. That's why we focus on delivering functionally active recombinant proteins backed by strong technical data and fast fulfillment.

Thousands of labs across academia, pharma, and biotech trust us to supply the proteins they need to push their work forward. Whether you're exploring TPO for regenerative medicine, hematological disorders, or stem cell therapy, we have the tools to help.

Ready to Order?

All TPO proteins listed on this page are available and in stock. Simply select the one that matches your experimental requirements and place your order directly through our website. If you're not sure which variant suits your needs best, feel free to contact our support team—we're here to help.

Let Beta LifeScience be your reliable partner in hematopoiesis research.