Recombinant Thrombopoietin (TPO) Proteins
12 products
Background
Thrombopoietin (TPO) is a key hematopoietic factor that is mainly involved in the production and regulation of platelets. The main function of TPO is to activate complex signaling pathways by binding to its receptor c-Mpl on the surface of platelets and megakaryocytes, promoting the differentiation of hematopoietic stem cells into megakaryocytes and ultimately the production of platelets.
TPO is essential for maintaining platelet number and function under normal physiological conditions. It affects the release and maturation of platelets by regulating the proliferation and differentiation of megakaryocytes. In addition, TPO also regulates the proliferation and self-renewal of hematopoietic stem cells in the bone marrow, maintaining the homeostasis of the hematopoietic system.
Due to the key role of TPO in maintaining platelet homeostasis, its abnormal expression or dysfunction is associated with some hematopoietic system diseases, such as thrombocytopenic purpura. Clinically, TPO receptor agonists have been widely used to treat diseases related to insufficient platelet production, such as idiopathic thrombocytopenic purpura.
Overall, TPO, as an important regulatory factor of the hematopoietic system, plays an irreplaceable role in platelet production and maintaining blood homeostasis.
Resources
Thrombopoietin (TPO) Blog Articles
Featured Products
| Cat. No. | Species | Product Description | Host | Structure | Purity | Activity | Features |
|---|---|---|---|---|---|---|---|
| BLPSN-4473 | Human | Human Thrombopoietin Protein (His Tag), Active | Mammalian cell | P40225 (1-353aa) | > 85 % | ED50: 50-200 ng/ml. | SDS-PAGE,Cell Based |
| BLPSN-4471 | Human | Human Thrombopoietin Protein (His Tag), Active | Mammalian cell | P40225 (22-353aa) | > 90 % | ED50: 10-60 ng/ml. | SDS-PAGE,Cell Based |
| BLPSN-4469 | Human | Human Thrombopoietin Protein (Fc Tag) | Mammalian cell | P40225 (1-192aa) | > 70 % | Not Test | SDS-PAGE |
| BLPSN-4470 | Human | Human Thrombopoietin Protein (His Tag) | Mammalian cell | P40225 (1-192aa) | > 85 % | Not Test | SDS-PAGE |
| BL-0277NP | Human | Human TPO Protein (N, C-6His) | Mammalian cell | P40225 (22-353aa) | > 95 % | Not Test | SDS-PAGE |
| Human | Human TPO Protein, Active | Mammalian cell | P40225 (22-353aa) | > 90 % | ED50: ≤1.0 ng/mL | SDS-PAGE,Cell Based | |
| BLPSN-4475 | Mouse | Mouse Thrombopoietin Protein (His Tag), Active | Mammalian cell | P40226 (1-356aa) | > 90 % | ED50: 1.6-6.4 ng/mL. | SDS-PAGE,Cell Based |
| BL-1133NP | Mouse | Mouse TPO Protein (N-6His) | Mammalian cell | P40226 (22-356aa) | > 95 % | Not Test | SDS-PAGE |
| BL-2895NP | Mouse | Mouse TPO Protein (C-6His) | Mammalian cell | P40226 (22-356aa) | > 90 % | Not Test | SDS-PAGE |
| BLPSN-4468 | Cynomolgus | Cynomolgus Thrombopoietin Protein (His Tag), Active | Mammalian cell | XP_005546625.1 (1-353aa) | > 86 % | ED50: 4-20 ng/mL. | SDS-PAGE,Cell Based |
