Native Human Renin Receptor Protein

Name: Native Human Renin Receptor Protein
Brand: Beta LifeScience
SKU: BLA-12047P
Availability: InStock

Collections: Enzymes, Protease, Recombinant proteins

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Product Overview

Host Species	Human
Accession	O75787
Synonym	APT6M8 9 APT6M8-9 ATP6AP2 ATP6IP2 ATP6M8-9 ATPase H(+)-transporting lysosomal accessory protein 2 ATPase H(+)-transporting lysosomal-interacting protein 2 ATPase H+ transporting lysosomal accessory protein 2 ATPase H+ transporting lysosomal interacting protein 2 ATPase H+ transporting lysosomal vacuolar proton pump membrane sector associated protein M8 9 ATPase membrane sector associated protein M8 9 ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8 9 CAPER ELDF10 Embryonic liver differentiation factor 10 ER localized type I transmembrane adaptor ER-localized type I transmembrane adaptor HT028 M8 9 M8-9 MGC99577 MRXE MSTP009 N14F Renin receptor Renin/prorenin receptor RENR_HUMAN V ATPase M8 9 subunit V ATPase M8.9 subunit V-ATPase M8.9 subunit Vacuolar ATP synthase membrane sector associated protein M8 9 Vacuolar ATP synthase membrane sector-associated protein M8-9 vacuolar proton ATP synthase membrane sector associated protein M8 9 XMRE
Description	Native Human Renin Receptor Protein is native.. It is a Full length protein
Source	Native
Purity	>95% SDS-PAGE.Prepared from frozen Human plasma using immobilized anti-Human Renin IgG.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Liquid Solution
Stability	The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution	See related COA
Unit Definition	For Research Use Only
Storage Buffer	Shipped on dry ice. Upon delivery aliquot and store at -80°C. Avoid freeze / thaw cycle.

Target Details

Target Function	Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, dendritic spine membrane. Cell projection, axon. Endosome membrane.
Database References	HGNC: 18305 OMIM: 300423 KEGG: hsa:10159 STRING: 9606.ENSP00000367697 UniGene: Hs.495960
Associated Diseases	Mental retardation, X-linked, with epilepsy (MRXE); Parkinsonism with spasticity, X-linked (XPDS)
Tissue Specificity	Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium,

Gene Functions References

Increased level of s (pro) RR in first trimester may be a marker for predicting gestational diabetes mellitus PMID: 27654965
Soluble (pro)renin receptor is dysregulated in pregnancies affected by diabetes mellitus, but not in preeclampsia. PMID: 29050747
maternal serum concentrations may reflect acceleration of tissue renin-angiotensin system in the placenta and blood pressure severity PMID: 28864001
The aim of this review, is to highlight new insights into the cellular and molecular mechanisms by which PRR may regulate UB branching, terminal differentiation and function of UB-derived collecting ducts, nephron progenitor maintenance, progression of nephrogenesis and normal structural kidney development and function--{REVIEW} PMID: 27160552
Overexpression of PRR is associated with pancreatic ductal adenocarcinoma. PMID: 28874965
the missense mutations in ATP6AP2 lead to impaired V-ATPase assembly and subsequent defects in glycosylation and autophagy. PMID: 29127204
High ATP6AP2 expression is associated with Renal Damage. PMID: 27228084
serum s(P)RR could be used as a marker for atherosclerotic conditions in hemodialysis patients PMID: 27367528
(P)RR may contribute to the homeostatic control of erythropoiesis. PMID: 28090037
Placental (P)RR can be involved in blood pressure regulation via the tissue RAS. On the other hand, plasma s(P)RR may be involved in the pathogenesis of decreased renal function in preeclampsia. PMID: 26684753
the present results suggest that ATP6AP2 rs5918007T might be susceptible factors for Essential Hypertension in Chinese Han population. PMID: 26625836
A mutation in the splice site following exon 2 may affect splicing due to its close proximity to the exon-intron boundary. It was associated with epilepsy, Parkinsonism and intellectual disability in 2 brothers. PMID: 26467484
Study identifies a renin-angiotensin system-independent function for the (P)RR in the regulation of LDL metabolism by controlling the levels of SORT1 and LDL receptor. PMID: 26582775
markedly expressed in adrenocortical zona glomerulosa and aldosterone-producing adenoma PMID: 25668351
Prorenin receptor promotes atrial structural and electric remodeling and plays an important role in the pathological development of atrial fibrillation. PMID: 25697868
Demonstrate that there are strong interactions between prorenin, ATP6AP2, and TGFB1 and that this system has a greater capacity in female amnion to stimulate profibrotic pathways, thus maintaining the integrity of the fetal membranes. PMID: 25491485
a novel GLP1R Interacting Protein ATP6ap2 PMID: 26272612
Crosstalk between (Pro)renin receptor and COX-2 in the renal medulla during angiotensin II-induced hypertension PMID: 25681793
This is the first demonstration that (P)RR may be profoundly involved in ductal tumorigenesis in the pancreas. PMID: 25747895
The binding of prorenin to PRR can promote proliferation and upregulate the anti-apoptotic protein Bcl-2 and downregulate the pro-apoptotic protein Bax independently PMID: 24591529
MicroRNA-152 represses VEGF and TGFbeta1 expressions through post-transcriptional inhibition of prorenin receptor in human retinal endothelial cells. PMID: 25802486
Data indicate that (pro)renin receptor ATP6PA2 interacts with the E1 beta subunit of pyruvate dehydrogenase and controlling its protein stability PMID: 25720494
expressed by lymphocytes and macrophages PMID: 25503726
activation of (P)RR and AT1R is associated with the pathogenesis of conjunctival EMZL by stimulating the production of FGF2 and MMPs. PMID: 25503453
The aim of this study was to analyse the contribution of constitutive (P)RR activity to its cellular effects and the relevance of prorenin glycosylation on its ligand activity. PMID: 24424509
The extracellular domain (ECD) and transmembrane domain (TM) of ATP6AP2 were indispensable for the biogenesis of active V-ATPase. PMID: 24223829
The expression of (P)RR in erythroid cells, raising the possibility that (P)RR may have a role in erythropoiesis and the pathophysiology of certain types of anemia. PMID: 22884881
Plasma levels of prorenin receptor are increased in heart failure patients with renal dysfunction. PMID: 23673200
This study demonstrates that the the extracellular domain of ATP6AP2 participates in dimerization. PMID: 24472541
Pro)renin receptor and insulin resistance: possible roles of angiotensin II-dependent and -independent pathways. [review] PMID: 22684035
Plasma sPRR concentrations are dependent on ethnicity and independent of renin, prorenin, and aldosterone concentrations in healthy subjects and in patients with contrasted degrees of renin-angiotensin system activity. PMID: 24218434
Studies indicated that various polymorphisms in the (P)RR/ATP6ap2 gene associated with increased cardiovascular risks. PMID: 24400720
Results show that reduction of the full-size ATP6AP2 transcript in XPDS cells and decreased level of ATP6AP2 protein in XPDS brain may compromise V-ATPase function and may ultimately be responsible for the pathology. PMID: 23595882
High s(P)RR concentration is associated with a lower SGA birth likelihood. PMID: 23555874
Report the presence of prorenin receptor in human substantia nigra. PMID: 22407459
The(pro)renin receptor mediates EGF receptor transactivation in both Ang II-dependent and -independent pathways. PMID: 23277024
These in vitro data indicate that prorenin acidified in vivo possibly modulate renin angiotensin system in (pro)renin receptor-dependent and/or -independent manners which could ultimately lead to the pathogenesis of diseases. PMID: 23111329
Our data using human samples provide the first evidence that prorenin receptor is associated with angiogenic activity in proliferative diabetic retinopathy. PMID: 22930161
Data indicate that high circulating levels of s(P)RR at early pregnancy predicted a subsequent elevation in blood pressure, and high concentrations at delivery were significantly associated with preeclampsia. PMID: 23045457
Prorenin is a chemotactic factor for human aortic smooth muscle cells expressing prorenin receptor. PMID: 22721990
(P)RR gene activity may be controlled by intracellular AngII. PMID: 21997900
Angiotensin generation depending on prorenin-(P)RR interaction may occur in transgenic rodents overexpressing prorenin several 100-fold. PMID: 22025376
Decidual prorenin may be involved in the labour-associated increase in amnion PGHS-2 abundance via the (pro)renin receptor. PMID: 20702505
that (P)RR influences blood pressure regulation in Caucasian men, potentially through altered aldosterone release PMID: 21346687
Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments. PMID: 21270819
The polymorphism of the (P)RR gene +1513A>G is associated with lacunar infarction and left ventricular hypertrophy in Japanese women. These results suggest that (P)RR has a role in organ damage in humans PMID: 21228785
Report expression (pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis. PMID: 21316680
the crystal structure of the PRR-IC domain as maltose-binding protein (MBP) fusion proteins at 2.0A (maltose-free) and 2.15A (maltose-bound) was reported. PMID: 21420935
Demonstrate that the (pro)renin receptor (PRR) is expressed in retinal pigment epithelium and may have a role in hypertensive exacerbation of dry age-related macular degeneration. PMID: 19580809
Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy PMID: 20385187

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

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Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

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