Recombinant Human beta 2 Defensin/BD2 Protein

Name: Recombinant Human beta 2 Defensin/BD2 Protein
Brand: Beta LifeScience
SKU: BLA-0141P
Availability: InStock

Collections: Cytokines and growth factors, Other cytokines, Recombinant proteins

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Product Overview

Host Species	Human
Accession	O15263
Synonym	BD 2 BD-2 BD2 beta 2 beta 2 Defensin Beta defensin 2 Beta defensin 4B Beta-defensin 2 Beta-defensin 4A DEF B2 DEF B4 DEFB 102 DEFB 2 DEFB 4 DEFB102 DEFB2 DEFB2, formerly DEFB4 DEFB4, formerly DEFB4B DEFB4P Defensin Defensin beta 2 Defensin, beta 4 Defensin, beta 4, pseudogene Defensin, beta 4A Defensin, beta 4B Defensin, beta, 2, formerly Defensin, beta, 4, formerly DFB4A_HUMAN HBD 2 hBD-2 HBD2 mBD-2 SAP 1 SAP1 Skin antimicrobial peptide 1 Skin-antimicrobial peptide 1
Description	Recombinant Human beta 2 Defensin/BD2 Protein was expressed in E.coli. It is a Full length protein
Source	E.coli
AA Sequence	GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Molecular Weight	4 kDa
Purity	>= 98% SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml.
Formulation	Lyophilised
Stability	The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution	See related COA
Unit Definition	For Research Use Only
Storage Buffer	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Target Details

Target Function	Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells.
Subcellular Location	Secreted.
Protein Families	Beta-defensin family, LAP/TAP subfamily
Database References	HGNC: 2767 OMIM: 602215 KEGG: hsa:100289462 STRING: 9606.ENSP00000424598 UniGene: Hs.105924
Tissue Specificity	Expressed in the skin and respiratory tract.

Gene Functions References

The encoded peptide has antimicrobial activity against E.coli, S. aureus, and P. aeruginosa. PMID: 9727055

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.