Recombinant Human C1QTNF4 Protein

Name: Recombinant Human C1QTNF4 Protein
Brand: Beta LifeScience
SKU: BL-2955PS
Availability: InStock

Collections: Cytokines and growth factors, Recombinant proteins, Tumor necrosis factors and receptors (tnfs)

Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

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Product Overview

Tag	His
Host Species	Human
Synonym	C1q and Tumor Necrosis Factor Related Protein 4, CTRP4, Complement-C1q Tumor Necrosis Factor-Related Protein 4, Complement C1q Tumor Necrosis Factor-Related Protein 4, ZACRP4, C1QTNF4.
Background	C1QTNF4 serves as a pro-inflammatory cytokine, which induces theactivation of NF-kappa-B signaling pathway and up-regulates IL6 production.
Description	C1QTNF4 Human Recombinant expressed in HEK293cells is a single, glycosylated, polypeptide chain (Leu17-Leu329) containing a total of 319a.a., having a calculated molecular weight of 34.5kDa and fused to a 6 a.a. His tag at C-Terminus.
Source	E.coli
AA Sequence	LGPTPGPGSS ELRSAFSAAR TTPLEGTSEM AVTFDKVYVN IGGDFDVATG QFRCRVPGAY FFSFTAGKAP HKSLSVMLVR NRDEVQALAF DEQRRPGARR AASQSAMLQL DYGDTVWLRL HGAPQYALGA PGATFSGYLV YADADADAPA RGPPAPPEPR SAFSAARTRS LVGSDAGPGP RHQPLAFDTE FVNIGGDFDA AAGVFRCRLP GAYFFSFTLG KLPRKTLSVK LMKNRDEVQA MIYDDGASRR REMQSQSVML ALRRGDAVWL LSHDHDGYGA YSNHGKYITF SGFLVYPDLA PAAPPGLGAS ELL HHHHHH.
Purity	>85.0% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	C1QTNF4 filtered (0.4µm) solution at a concentration of 0.25mg/ml in phosphate buffered saline.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.