Recombinant Human FGF17 Protein

Name: Recombinant Human FGF17 Protein
Brand: Beta LifeScience
SKU: BLPSN-2038
Availability: InStock

Collections: Cytokines and growth factors, Enzymes, Growth factors and receptors, Kinase, Recombinant proteins

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Product Overview

Tag	N/A
Host Species	Human
Accession	O60258
Synonym	FGF17, FGF-13, HH20, FGF-17, fibroblast growth factor 17
Background	FGF17 (Fibroblast Growth Factor 17) is a Protein Coding gene. Diseases associated with FGF17 include Hypogonadotropic Hypogonadism 20 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism. Among its related pathways are Signaling by activated point mutants of FGFR3 and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.
Description	A DNA sequence encoding the mature form of human FGF17 (Thr23-Thr216) was expressed, with a N-terminal Met.
Source	E.coli
Predicted N Terminal	Met
AA Sequence	Thr23-Thr216
Molecular Weight	The recombinant human FGF17 consists of 195 amino acids and predicts a molecular mass of 22.6 KDa. It migrates as an approximately 21 and 23 KDa band in SDS-PAGE under reducing conditions.
Purity	(39.1+60.0)% as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Bioactivity	Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts.The ED50 for this effect is typically 0.6-3 ug/mL.
Formulation	Recombinant Human FGF17 Protein was lyophilized from sterile 50mM Tris, 1M NaCl, PH 8.5
Stability	Recombinant Human FGF17 protein is stable up to 1 year at -70°C
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Target Details

Target Function	Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
Subcellular Location	Secreted.
Protein Families	Heparin-binding growth factors family
Database References	HGNC: 3673 OMIM: 603725 KEGG: hsa:8822 STRING: 9606.ENSP00000352414 UniGene: Hs.248192
Associated Diseases	Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)
Tissue Specificity	Preferentially expressed in the embryonic brain.

Gene Functions References

FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism. PMID: 23643382
FGF17 expression is increased 2-fold in benign prostatic hyperplasia and may contribute to the increased epithelial proliferation seen in this disease. PMID: 15129425

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.