Recombinant Human FGF9 Protein (Fc Tag)

Name: Recombinant Human FGF9 Protein (Fc Tag)
Brand: Beta LifeScience
SKU: BLPSN-2051
Availability: InStock

Collections: Cytokines and growth factors, Enzymes, Growth factors and receptors, Kinase, Recombinant proteins

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Product Overview

Tag	Fc
Host Species	Human
Accession	NP_002001.1
Synonym	FGF9, FGF-9, GAF, HBFG-9, HBGF-9, SYNS3, fibroblast growth factor 9
Background	FGF9 (Fibroblast Growth Factor 9) is a Protein Coding gene. Diseases associated with FGF9 include Multiple Synostoses Syndrome 3 and Multiple Synostoses Syndrome. Among its related pathways are Signaling by activated point mutants of FGFR3 and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF20.
Description	A DNA sequence encoding the mature form of human fibroblast growth factor 9 (Leu 4-Ser 208) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Source	HEK293
Predicted N Terminal	Glu 20
AA Sequence	Leu 4-Ser 208
Molecular Weight	The recombinant human Fc/FGF9 is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a predicted molecular mass of 54 and 37 kDa as estimated in SDS-PAGE under reducing conditions duo to glycosylation.
Purity	(81.9 + 13.9)%, as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Measured in a cell proliferation assay using Balb/c3T3 mouse embryonic fibroblasts.The ED50 for this effect is typically 1-3 ng/mL.
Formulation	Recombinant Human FGF9 Protein (Fc Tag) was lyophilized from sterile PBS, pH 7.4
Stability	Recombinant Human FGF9 protein is stable up to 1 year at -70°C
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.