Recombinant Human IL-23R Protein (C-Fc)

Name: Recombinant Human IL-23R Protein (C-Fc)
Brand: Beta LifeScience
SKU: BL-0151NP
Availability: InStock

BL-0151NP: Greater than 90% as determined by reducing SDS-PAGE. (QC verified)

Collections: Cytokines and growth factors, Interleukins and receptors, Recombinant proteins

Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

Submit an inquiry today to inquire about all available size options and prices! Connect with us via the live chat in the bottom corner to receive immediate assistance.

Product Overview

Description	Recombinant Human Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp353 is expressed with a human IgG1 Fc tag at the C-terminus.
Accession	Q5VWK5
Synonym	Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R
Gene Background	Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
Molecular Mass	65 KDa
Apmol Mass	90-120 KDa, reducing conditions
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Endotoxin	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Purity	Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Biological Activity	Biologically active. Please contact us to obtain bioactivity data.
Reconstitution	Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Usage	For Research Use Only

Target Details

Target Function	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Protein Families	Type I cytokine receptor family, Type 2 subfamily
Database References	HGNC: 19100 OMIM: 607562 KEGG: hsa:149233 STRING: 9606.ENSP00000321345 UniGene: Hs.677426
Associated Diseases	Inflammatory bowel disease 17 (IBD17)
Tissue Specificity	Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Gene Functions References

IL23R (rs10889677) polymorphism did not show any association with rheumatic heart disease in South Indian population PMID: 29985710
Study confirms an association between IL12B and IL23R genetic polymorphism and psoriasis vulgaris (with a protective effect of minor alleles). PMID: 29454820
The IL23R gene rs10889677 A allele confers increased risk of ankylosing spondylitis (AS) in Europeans, but its role in Asian populations needs further exploration. PMID: 29198991
these findings suggest that the variants +2199 A/C IL-23R and -197 G/A IL-17A could contribute to rheumatoid arthritis development in the studied population PMID: 28547498
Data show that interleukin-23 receptor (IL-23R) single nucleotide polymorphism (SNP) rs11465817 contributes to the risk of recurrent oral ulceration (ROU) in Chinese. PMID: 29169427
Findings indicate that IL17A -197 G/A and IL23R H3Q are not associated with susceptibility to MM. However, IL-17 and IL-23R polymorphisms may affect severity, bone lesions, and extra-medullary disease in patients with MM. PMID: 28786198
This study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3, ABCB1 and IL23R) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk. PMID: 28422712
genetic association studies in population in southwest China: Data suggest that SNPs in STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) are associated with occurrence, severity, and immunosuppressive therapy outcomes of aplastic anemia in the population studied. (STAT = signal transducer and activator of transcription) [article includes Meta-Analysis] PMID: 29330562
Study provides a comprehensive examination of the available evidence for the association between polymorphisms in the IL-23R gene and ulcerative colitis (UC). The meta-analysis suggests that IL-23R gene polymorphisms are associated with UC susceptibility, especially in Caucasians. PMID: 27902482
Data indicate that the interleukin-23 receptor (IL-23R) SNPs rs11209026, p.Arg381Gln; rs41313262 p.Val362Ile were not associated with susceptibility to inflammatory bowel disease (IBD) in Chinese Han population. PMID: 27765927
Interleukin-23 receptor cytokine-binding homology region balances the ratio of Th17/Th9/Treg cells in collagen-induced arthritis. PMID: 27177334
this meta-analysis suggests that each allele of IL-23R, including rs7519847, rs17375018 and rs11209032 was negatively associated with uveitis; however, homozygote models, including the rs17375018 GG genotype and rs11209032 AA genotype, were significantly associated with uveitis PMID: 28558665
an evaluation of what is currently known about the protective role of R381Q variant in IL-23R gene in immune-based diseases (Review). PMID: 27043356
Th17 cells expressed consistent high levels of the IL-12Rbeta1 subunit, which appeared a better predictor of responsiveness to IL-23 than the expression of the IL-23R subunit. PMID: 27645493
We conclude that variants in IL-23A and IL-23R genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases. PMID: 27893410
IL-23 R (rs7517847) and LEP (rs7799039) polymorphisms were associated with an increased risk but not affecting the clinical presentation of HCC among Egyptian patients PMID: 28452232
In a Turkish population, IL23R polymorphism is a risk factor for UC and is protective against CD. PMID: 27852544
The current study emphasizes the lack of association of IL23R and IL17 polymorphisms with rheumatoid arthritis susceptibility in the Algerian population. However, the data showed the relationship between IL23R and IL17A polymorphisms and the production of the different RF isotypes in rheumatoid arthritis patients PMID: 27606475
Haplotype of non-synonymous IL-23R variants increase susceptibility to severe malarial anemia in children of a holoendemic P. falciparum transmission area. PMID: 28427357
there is a positive association between the GWAS reported rs3762318 and leprosy, and SLC35D1 and IL23R might be the causal genes PMID: 27712858
this study identified susceptibility single nucleotide polymorphisms in IL23R with Behcet's disease in Han Chinese PMID: 27464962
HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci. PMID: 27548383
Study identified a possible silencer downstream of IL23R that includes the ankylosing spondylitis (AS)-associated SNP rs924080, which appears to modulate the functional effects of this regulatory element; confirmed the primary association of AS with rs11209032 in this region, but suggest that there could be a possible additional effect from rs924080 in a putative silencer on the same haplotype. PMID: 28381868
Study demonstrated susceptible or protective character of the investigated IL23R SNPs on the phenotype of ulcerative colitis, confirming the genetic association. PMID: 28210080
In ankylosing spondylitis, conditional analysis identified rs11209032 as the probable causal single-nucleotide polymorphism within a 1.14 kb putative enhancer between IL23R and IL12RB2. The rs11209032 single-nucleotide polymorphism downstream of IL23R forms part of an enhancer, allelic variation of which may influence Th1-cell numbers. PMID: 26916345
Results did not show any strong association between IL-23R polymorphisms and juvenile idiopathic arthritis or serum IL-17A levels in Iranian patients. PMID: 26016922
The results of this case-control study suggest that IL-12A, IL-12B, IL12RB1, IL12RB2 and IL23R make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations PMID: 26987707
this study shows a lack of association of the IL-23 single nucleotide polymorphisms with the risk of acute lymphoblastic leukemia in Iran PMID: 28341819
The interleukin-23 receptor gene polymorphism may not contribute to the susceptibility of development of primary immune thrombocytopenia in Egyptian children. PMID: 26859125
this study shows that there is no significant difference in mucosal IL-23R expression in Ulcerative Colitis patients with moderate-to-severe disease activity compared to those in remission PMID: 27178149
In this study, we were unable to establish a correlation between the IL-23R SNPs investigated and HLA-B27-associated acute anterior uveitis as well as idiopathic intermediate uveitis. PMID: 27009486
These results suggest that IL23R may contribute to the development of intracerebral hemorrhage. PMID: 26846416
The association of IL-23R and Ankylosing Spondylitis (AS) that is seen in Caucasian patients with AS is not present in Chinese patients with AS. PMID: 27650612
Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which might limit IL-23-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL-23R. PMID: 26961870
genetic polymorphism is associated with psoriasis in the South Indian Tamils PMID: 26472011
A significant association was found between all Crohn's disease and the rs7517847 polymorphism, especially in Caucasians. PMID: 26678098
The IL23R polymorphisms rs10889677, rs7517847, and the IL12B polymorphism rs3212227 are not associated with multiple sclerosis risk. PMID: 26000455
results suggest a convergent cause of IL23Ralpha variant protection against chronic inflammatory disease. PMID: 26887945
meta-analysis supports that two polymorphisms (rs11209026 and rs7517847) in the IL-23 gene may be considered to be protective factors against developing UC among Caucasian populations. PMID: 25497273
The results of the current study disclosers1343151 variant of IL23R as a susceptibility gene in CD. PMID: 25561320
Lower LCN2 levels in Crohn's Disease patients carrying IBD risk-increasing IL23R variants may result from a restricted upregulation of LCN2 due to an impaired Th17 immune response PMID: 26263469
IL23 receptor single nucleotide polymorphisms and gene copy number variation are associated with susceptibility to pulmonary tuberculosis in Chinese Uygurs. PMID: 26626589
These results indicated an association between the rs11209026 G>A polymorphism of the IL-23 receptor gene and the risk of atherosclerosis. PMID: 26261042
Low-Frequency IL23R Coding Variant is Associated with Crohn's Disease Susceptibility. PMID: 26375822
R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma. PMID: 26547706
GG genotype of the rs17375018 variant in the IL-23R gene enhances pro-inflammatory cytokine responses in Behcet's Disease. PMID: 26222305
it is concluded that the frequency of single nucleotide polymorphism in the IL-23 receptor (R381Q) in patients with recurrent spontaneous abortion (RSA) is less than that found in normal control women. PMID: 26269135
review and meta-analysis of association of polymorphisms rs6682925, rs10889677 and rs1884444 with cancer risk PMID: 26717375
Copy number variation of exon 11 in IL-23R is associated with pulmonary tuberculosis in the Chinese Uygur population. PMID: 26829744
IL-17A and IL-23R gene polymorphism were not associated with acute myeloid leukemia susceptibility. PMID: 26191290

FAQs

Please fill out the Online Inquiry form located on the product page. Key product information has been pre-populated. You may also email your questions and inquiry requests to sales1@betalifesci.com. We will do our best to get back to you within 4 business hours.

Feel free to use the Chat function to initiate a live chat. Our customer representative can provide you with a quote immediately.

Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.