Recombinant Human TNFRSF10C Protein

Name: Recombinant Human TNFRSF10C Protein
Brand: Beta LifeScience
SKU: BL-0848PS
Availability: InStock

Collections: Cytokines and growth factors, Recombinant proteins, Tumor necrosis factors and receptors (tnfs)

Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

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Product Overview

Tag	N/A
Host Species	Human
Synonym	Tumor Necrosis Factor Receptor Superfamily, Member 10c,Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-RelatedApoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L,Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, DecoyReceptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAILReceptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAILReceptor, CD263 Antigen, DCR1-TNFR, CD263.
Background	TRAIL Receptor-3, also known as TNFRSF10C belongs to the TNF-receptorsuper family. TNFRSF10C contains an extracellular TRAIL-binding domain as wellas a transmembrane domain, however no cytoplasmicdeath domain. Furthermore, TNFRSF10C is not capable of inducing apoptosis, andis considered to act as an antagonistic receptorwhich protects cells from TRAIL-induced apoptosis.
Description	TNFRSF10C Human Recombinant expressed in E. coli is asingle, non-glycosylated polypeptide chain containing 234a.a. (26-236 a.a)and having a molecular weight of 24.6 kDa.TNFRSF10C is fused to a 23a.a. His-tag atN-terminus and purified by unique purification methods.
Source	E.coli
AA Sequence	MGSSHHHHHHSSGLVPRGSH MGSATTARQEEVPQQTVAPQ QQRHSFKGEE CPAGSHRSEH TGACNPCTEG VDYTNASNNE PSCFPCTVCK SDQKHKSSCTMTRDTVCQCK EGTFRNENSP EMCRKCSRCP SGEVQVSNCT SWDDIQCVEE FGANATVETP AAEETMNTSPGTPAPAAEET MNTSPGTPAP AAEETMTTSP GTPAPAAEET MTTSPGTPAP AAEETMTTSP GTPA.
Purity	Greaterthan 90.0% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	TNFRSF10C protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4) and 10% glycerol.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.