Recombinant Rat RBP4 Protein

Name: Recombinant Rat RBP4 Protein
Brand: Beta LifeScience
SKU: BLA-1896P
Availability: InStock

Collections: Cytokines and growth factors, Growth factors and receptors, Recombinant proteins

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Product Overview

Host Species	Rat
Accession	P04916
Synonym	OTTHUMP00000020114 OTTHUMP00000020115 OTTHUMP00000020116 Plasma retinol binding protein 4 Plasma retinol-binding protein Plasma retinol-binding protein(1-176) PRBP PRO2222 RBP RBP4 RDCCAS RET4_HUMAN Retinol binding protein 4 Retinol binding protein 4 interstitial Retinol binding protein 4 plasma
Description	Recombinant Rat RBP4 Protein was expressed in HEK293. It is a Full length protein
Source	HEK293
Molecular Weight	23 kDa including tags
Purity	Greater than 90% SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Liquid Solution
Stability	The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution	See related COA
Unit Definition	For Research Use Only
Storage Buffer	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycle.

Target Details

Target Function	Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Subcellular Location	Secreted.
Protein Families	Calycin superfamily, Lipocalin family
Database References	KEGG: rno:25703 STRING: 10116.ENSRNOP00000021055 UniGene: Rn.108214
Tissue Specificity	Detected in blood plasma (at protein level).

Gene Functions References

RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.