Recombinant Human TAC1 Protein (N-6His)

Name: Recombinant Human TAC1 Protein (N-6His)
Brand: Beta LifeScience
SKU: BL-1568NP
Availability: InStock

BL-1568NP: Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Collections: Other recombinant proteins, Recombinant proteins

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Product Overview

Description	Recombinant Human Protachykinin-1 is produced by our E.coli expression system and the target gene encoding Glu20-Arg129 is expressed with a 6His tag at the N-terminus.
Accession	P20366
Synonym	Protachykinin-1; PPT; TAC1
Gene Background	Protachykinin-1(TAC1) is a secreted protein and belongs to the tachykinin family. TAC1 is encoded by the TAC1 gene. This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues.
Molecular Mass	15.2 KDa
Apmol Mass	14-18 KDa, reducing conditions
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, 2M Urea, 1mM EDTA, pH 8.0.
Endotoxin	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Biological Activity	Not tested
Reconstitution
Storage	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Usage	For Research Use Only

Target Details

Target Function	Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Location	Secreted.
Protein Families	Tachykinin family
Database References	HGNC: 11517 OMIM: 162320 KEGG: hsa:6863 STRING: 9606.ENSP00000321106 UniGene: Hs.2563

Gene Functions References

Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P < 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta. Mast cell secretion of IL-1beta in response to SP and IL-33 reveals targets for the development of antiinflammatory therapies. PMID: 30232261
High TAC1 expression is associated with primary central nervous system lymphoma. PMID: 28521029
These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells. PMID: 28500728
This study showed that ADMA, carbonyl groups, CAT and NKA can be useful markers of chronic stress in both males and females with depression, PTSD, and depression concurrent with PTSD. PMID: 28554099
Inhibition of SP through use of a neurokinin 1 (NK1) antagonist is highly beneficial following both traumatic brain injury (TBI) and ischaemic stroke in pre-clinical models. The role of CGRP is more unclear, especially with respect to TBI, with both elevations and reductions in CGRP levels reported following trauma PMID: 28817088
serum SP levels during the first week could be used as a biomarker of sepsis mortality. PMID: 28714876
elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis. PMID: 28460633
High methylation of TAC1 is associated with head and neck cancer. PMID: 27027429
Data suggest that serum substance P concentrations at the day of oocyte retrieval after ovulation induction may be used to predict oocyte maturation during in vitro oocyte maturation to be followed by intracytoplasmic sperm injections and may be an indirect indicator for treatment outcome in women with infertility. PMID: 27908224
expressed in mural granulosa and cumulus cells PMID: 27146034
Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata. PMID: 27456549
These results suggest that Substance P can retain the therapeutic effect of adipose-derived stem cells by elevating their proliferative and paracrine potential in ex vivo culture. PMID: 28192115
Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P exhibits fast association kinetics; neurokinin A exhibits slow association kinetics. PMID: 27501920
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported. PMID: 28423013
Circulating Neurokinin A >/= 50 ng/L is a strong indicator of poor prognosis when Neurokinin A remains above this concentration PMID: 26038607
Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/beta-arrestin 2/Rho A signaling pathway. PMID: 26852662
Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease PMID: 24969128
Report absence of full-length neurokinin-1 receptor protein expression by cutaneous T cells in mycosis fungoides and discuss substance P signaling. PMID: 25783846
findings suggest a proinflammatory role for SP in autoimmune inflammation PMID: 25690155
The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented. PMID: 26349209
Substance P was significantly increased in hypertrophic scars compared with matched unburned skin. In the reticular dermis and papillary dermis, SP represented significant correlation with pain. PMID: 24908181
High TAC1 expression is associated with breast cancer. PMID: 25750171
An increased presence of Substance P in the trochanteric bursa may be related to the pain associated with greater trochanteric pain syndrome. PMID: 24563019
Substance P is upregulated in the serum of patients with chronic spontaneous urticaria PMID: 24844859
SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly. PMID: 23977290
we define a three-gene panel, CDO1, HOXA9, and TAC1, which we subsequently validate in two independent cohorts of primary NSCLC samples PMID: 24486589
The results showed that the expression of SP and CGRP was significantly enhanced in the neurogenic SMSCs in response to IL-1beta, IL-6 and TNF-alpha, and the effect was remarkably inhibited by HA. PMID: 25135735
The antimicrobial peptide substance P has activity against invasive bacteria and fungi. PMID: 12074933
TAC1 expression level was differentially altered in Crohn disease and ulcerative colitis patients. PMID: 23827863
study investigated the role of SP in promoting the development of brain tumors; an increase in the levels of SP was noted in brain tumors; results suggest that SP and its NK1 receptor may play a major role in the progression of certain types of brain tumors PMID: 24374326
SP induces higher levels of CD163 in monocytes and that high expression of CD163 is associated with increases HIV infection in macrophages. PMID: 24577568
Substance P may be protective acutely following ischemia-reperfusion, but damaging long-term in non-ischemic induced remodeling and heart failure. PMID: 24286592
Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth. PMID: 24603459
Copper(II) complexes of neuropeptide gamma with point mutations (S8,16A) products of metal-catalyzed oxidation. PMID: 24084156
Data indicate that both nucleus pulposus (NP) and annulus fibrosus (AF) cells expressed Substance P (SP) at low levels. PMID: 23873242
Substance P does not play any important role in pruritus in hemodialysed and peritoneal dialyzed patients. PMID: 23995243
Serum methylation levels of TAC1, SEPT9, and EYA4 were significant discriminants between stage I colorectal cancer and healthy controls. PMID: 23862763
TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome. PMID: 24010162
The results showed that SP is present in the gengival sulcus in elements undergoing orthodontic forces during treatment with Invisalign technique and not in the control teeth. PMID: 23737731
Our results suggest that Substance P plays an important role in the development of pancreatic cancer metastasis and PNI, and blocking the SP/NK-1R signaling system is a novel strategy for the treatment of pancreatic cancer. PMID: 23345604
Data indicate that circulating substance P (SP) and TGF-beta1 levels are increased in patients with myelofibrosis. PMID: 22906243
CpG hypermethylation is a likely mechanism of TAC1 and TACR1 gene inactivation, supporting the hypothesis that TAC1 and TACR1 play a role in the tumorigenesis of HNSCC and that this hypermethylation may serve as an important biomarker. PMID: 23420374
SP stimulates complement C3 secretion in adipocytes, and expression of NK1R in human omental adipose tissue correlates with plasma complement C3. PMID: 23257919
Elevated substance P levels might be regarded as an important contributor of sulfur mustard-induced chronic pruritus and a potential target for reducing the symptoms PMID: 22681041
Expression of esophageal epithelial CGRP and substance P is increased, and correlates negatively with perception thresholds in non-erosive reflux disease. PMID: 22961239
This study aims to explore the associations of polymorphisms in tachykinin, precursor 1 (TAC1), tachykinin receptor 1 (TACR1), and tachykinin receptor 2 (TACR2) genes and their interactions with the risk of colorectal cancer among Chinese population. PMID: 22733436
This study indicates that SP, mediated via NK-1 R, increases collagen remodeling and leads to increased MMP3 mRNA and protein expression that is further enhanced by cyclic mechanical loading. PMID: 22836729
These data suggest a direct relationship between central nervous system substance P containing neural circuits and aggression in human subjects PMID: 22449753
Tissue and serum levels of substance P were increased in chronic pancreatitis, while neprilysin levels remained unaltered. PMID: 22572771
The unique co-existence of SP and phospho-NMDAR1 in tendinopathy presumably reflects a tissue proliferative and nociceptive role. PMID: 22354721

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